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Earlier beta-blockers like Inderal propanolol are non-selective and can produce asthma in some patients by activating receptors in the lung. USES: This medication is beta-blocker used to treat chest pain angina heart donde comprar toprol failure, and high blood pressure. Many of the calcium channel blockers slow heart rate and are well tolerated. Toprol-XL administered once day, and immediate release meToprolol administered once to four times day, provided comparable total beta1-blockade over 24 hours area under the beta1-blockade versus time curve in the dose range 100 mg. Toprol-XL, in dosages of 100 to 400 mg once daily, produces similar 1-blockade as conventional meToprolol tablets administered two to four times daily. Bronchospasm: beta2-stimulating agent and or theophylline derivative should be administered. When discontinuing chronically administered TOPROL-XL, particularly in patients with ischemic heart disease, the dosage should be gradually reduced over period of 1-2 weeks and the patient should be carefully monitored.